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Original Papers

Hage C, Iacobucci C, Rehkamp A, Arlt C, Sinz A., The First Zero-Length Mass Spectrometry-Cleavable Cross-Linker for Protein Structure Analysis. Angew Chem Int Ed Engl 56:14551-14555 (2017) PubMed

Iacobucci C, Sinz A., To Be or Not to Be? Five Guidelines to Avoid Misassignments in Cross-Linking/Mass Spectrometry. Anal Chem 89, 7832-7835 (2017) PubMed

Iacobucci C, Hage C, Schäfer M, Sinz A., A Novel MS-Cleavable Azo Cross-Linker for Peptide Structure Analysis by Free Radical Initiated Peptide Sequencing (FRIPS). J Am Soc Mass Spectrom 28:2039-2053 (2017) PubMed

Götze M, Dufourt J, Ihling C, Rammelt C, Pierson S, Sambrani N, Temme C, Sinz A, Simonelig M, Wahle E., Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch. RNA 23: 1552 - 1568 (2017) PubMed

Hage C, Falvo F, Schäfer M, Sinz A., Novel Concepts of MS-Cleavable Cross-linkers for Improved Peptide Structure Analysis. J Am Soc Mass Spectrom 28:2022-2038(2017) PubMed

Bilova T, Paudel G, Shilyaev N, Schmidt R, Brauch D, Tarakhovskaya E, Milrud S, Smolikova G, Tissier A, Vogt T, Sinz A, Brandt W, Birkemeyer C, Wessjohann LA, Frolov A., Global Proteomic Analysis of Advanced Glycation End Products in the Arabidopsis Proteome Provides Evidence for Age-related Glycation Hotspots. J Biol Chem 292:15758-15776 (2017) PubMed

Lindner S, Gruhle K, Schmidt R, Garamus VM, Ramsbeck D, Hause G, Meister A, Sinz A, Drescher S., Azide-Modified Membrane Lipids: Synthesis, Properties, and Reactivity. Langmuir 33, 4960-4973 (2017) PubMed

Häupl B, Ihling CH, Sinz A., Combining affinity enrichment, cross-linking with photo-amino acids, and mass spectrometry for probing protein kinase D2 interactions. Proteomics. [Epub ahead of print] (2017) PubMed

Lipstein N, Göth M, Piotrowski C, Pagel K, Sinz A, Jahn O., Presynaptic Calmodulin targets: lessons from structural proteomics. Expert Rev Proteomics 14, 223-242 (2017) PubMed

Schmidt R., Sinz A., Improved single-step enrichment methods of cross-linked products for protein structure analysis and protein interaction mapping. Anal Bioanal Chem 409, 2393-2400 (2017) PubMed

Arlt C, Flegler V, Ihling CH, Schäfer M, Thondorf I, Sinz A., An Integrated Mass Spectrometry-Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor. Angew Chem Int Ed Engl 56, 275-279 (2017) PubMed

Paudel G., Bilova T., Schmidt R., Greifenhagen U., Berger R., Tarakhovskaya E., Stöckhardt S., Balcke GU., Humbeck K., Brandt W., Sinz A., Vogt T., Birkemeyer C., Wessjohann L., Frolov A., Osmotic stress is accompanied by protein glycation in Arabidopsis thaliana. J Exp Bot. 67, 6283-6295 (2016) PubMed

Buttstedt A., Ihling CH., Pietzsch M., Moritz RF., Royalactin is not a royal making of a queen. Nature 537, E10-2 (2016) PubMed

Schumann, M., Ihling, C.H., Prell, E., Schierhorn, A., Sinz, A., Fischer G, Schiene-Fischer C, Malešević M., Identification of low abundance cyclophilins in human plasma. Proteomics 16, 2815 - 2826 (2016) Online

Kölbel, K., Warnke, S., Seo, J., von Helden, G., Moretti, R., Meiler, J., Pagel, K., Sinz, A., Conformational Shift of a β-Hairpin Peptide upon Complex Formation with an Oligo–proline Peptide Studied by Mass Spectrometry. ChemistrySelect 1, 3651 -3656 (2016) Online

Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A., Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines. Proteomics 16, 2801-2814 (2016) PubMed

Häupl B , Ihling CH, Sinz A., Protein Interaction Network of Human Protein Kinase D2 Revealed by Chemical Cross-linking/Mass Spectrometry . J Proteome Res. 15, 3686-3699 (2016) PubMed

Arlt C, Goetze M, Ihling CH, Hage C, Schaefer M, Sinz A., Integrated Workflow for Structural Proteomics Studies Based on Cross-Linking/Mass Spectrometry with an MS/MS Cleavable Cross-Linker. Anal Chem. 88, 7930-7 (2016) PubMed

Hage C, Ihling CH, Götze M, Schäfer M, Sinz A., Dissociation Behavior of a TEMPO-Active Ester Cross-Linker for Peptide Structure Analysis by Free Radical Initiated Peptide Sequencing (FRIPS) in Negative ESI-MS. J Am Soc Mass Spectrom. 28, 56-68 (2017) PubMed

Schwarz R, Tänzler D, Ihling CH, Sinz A., Monitoring Solution Structures of Peroxisome Proliferator-Activated Receptor β/δ upon Ligand Binding. PLoS One. 11, e0151412 (2016) PubMed

Lössl P, Sinz A., Combining Amine-Reactive Cross-Linkers and Photo-Reactive Amino Acids for 3D-Structure Analysis of Proteins and Protein Complexes. Methos Mol Biol. 1394, 109-27 (2016) PubMed

Köhn M, Ihling CH, Sinz A, Krohn K, Hüttelmaier S., The Y3** ncRNA promotes the 3' end processing of histone mRNAs. Genes Dev. 29, 1998-2003 (2015) PubMed

Ihling A, Ihling CH, Sinz A, Gekle M., Acidosis-Induced Changes in Proteome Patterns of the Prostate Cancer-Derived Tumor Cell Line AT-1. J Proteome Res. 14, 3996-4004 (2015) PubMed

Sinz A, Arlt C, Chorev D, Sharon M., Chemical Cross-Linking and Native Mass Spectrometry: A Fruitful Combination for Structural Biology. Protein Sci. 24, 1193-209 (2015) PubMed

Ihling CH, Falvo F, Kratochvil I, Sinz A, Schäfer M., Dissociation behavior of a bifunctional tempo-active ester reagent for peptide structure analysis by free radical initiated peptide sequencing (FRIPS) mass spectrometry. J Mass Spectrom. 50, 396-406 (2015) PubMed

Piotrowski C, Ihling CH, Sinz A., Extending the cross-linking/mass spectrometry strategy: Facile incorporation of photo-activatable amino acids into the model protein calmodulin in Escherichia coli cells. Methods. 89, 121-7 (2015) PubMed

Arlt C, Ihling CH, Sinz A., Structure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry. Proteomics. 15, 2746-55 (2015) PubMed

Götze, M., Pettelkau, J., Fritzsche R., Ihling, CH., Schäfer, M., Sinz, A., Automated Assignment of MS/MS Cleavable Cross-Links in Protein 3D-Structure Analysis. J Am Soc Mass Spectrom. 26, 83-97 (2015) PubMed

Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A., Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes. PLoS One. 9, e112886 (2014) PubMed

Zorn, M ., Ihling, CH., Golbik, R., Sawers, RG., Sinz, A., Mapping Cell Envelope and Periplasm Protein Interactions of Escherichia coli Respiratory Formate Dehydrogenases by Chemical Cross-linking and Mass Spectrometry. J Proteome Res. 13, 5524-35 (2014) PubMed

Pettelkau, J., Ihling, CH., Frohberg, P., van Werven, L., Sinz, A., Reliable Identification of Cross-Linked Products in Protein Interaction Studies by (13)C-Labeled p-Benzoylphenylalanine. J Am Soc Mass Spectrom. 25 1628-1641 (2014) PubMed

Doberenz, C., Zorn, M., Falke, D., Nannemann, D., Hunger, D., Beyer, L., Ihling, CH., Meiler, J., Sinz, A., Sawers, RG., Pyruvate Formate-Lyase Interacts Directly with the Formate Channel FocA to Regulate Formate Translocation. J Mol Biol. 426, 2827-2839 (2014) PubMed

Herbst, S., Lipstein, N., Jahn, O., Sinz, A., Structural Insights into calmodulin/Munc13 interaction. Biol Chem. 395, 763-768 (2014) PubMed

Ihling, CH., Schröder, T., Pettelkau, J., Tischer, A., Sinz, A., Accessibilities of N-terminal myristoyl chain and cysteines in guanylyl cyclase-activating protein-2 (GCAP-2) studied by covalent lableing and mass spectrometry. Rapid Commun Mass Spectrom. 28, 835-838 (2014) PubMed

Simon, C., Klose, T., Herbst, S., Han, BG., , Sinz, A., Glaeser, RM., Stubbs, MT., Lilie, H., Disulfide Linkage and Structure of Highly Stable Yeast-derived Virus-Particles of Murine Polyomavirus. J Biol Chem. 289, 10411-10418 (2014) PubMed

Herbst, S., Maucher, D., Schneider, M. , Ihling, CH., Jahn, O., Sinz, A., Munc13-2-Like skMLCK Variants Cannot Mimic the Unique Calmodulin Binding Mode of Munc13 as Evidenced by Chemical Cross-Linking and Mass Spectrometry. PLoS One. 8, e75119 (2013) PubMed

Herbst, S., Masada, N., Pfennig, S., Ihling CH., Cooper, D., Sinz, A., Structural insights into calmodulin/adenylyl cyclase 8 interaction. Anal Bioanal Chem. 405, 9333-9342 (2013) PubMed

Pettelkau, J. , Thondorf, I., D., Theisgen, S., Lilie, H., Schröder, T., Arlt, C., Ihling, CH., Sinz, A., Structural Analysis of Guanylyl Cyclase-Activating Protein-2 (GCAP-2) Homodimer by Stable Isotope-Labeling, Chemical Cross-Linking, and Mass Spectrometry. J Am Soc Mass Spectrom. 24, 1967-1979 (2013) PubMed

Schwarz, R., Tänzler, D., Ihling, CH., Müller, MQ., Kölbel, K., Sinz, A., Monitoring Conformational Changes in Peroxysome Proliferator-Activated Receptor alpha by a Genetically Encoded Photo-Amino Acid, Cross-Linking and Mass Spectrometry. J Med Chem. 56, 4252-4263 (2013) PubMed

Zorn, M., Ihling, CH., Golbik, R., Sawers, RG., Sinz, A., Selective selC-Independent Selenocysteine Incorporation into Formate Dehydrogenases. PLoS One. 8, e61913 (2013) PubMed

Buttstedt A., Wostradowski, T., Ihling, C., Hause, G., Sinz, A., Schwarz, E., Different morphology of amyloid fibrils originating from agitated and non-agitated conditions. Amyloid. 20, 86-92 (2013) PubMed

Wolf, A., Rietscher, K., Glaß, M., Hüttelmaier, S., Schutkowski, M., , Ihling, C., Sinz A., Wingenfeld, A., Mun, A., Hatzfeld, M., V., Insulin signaling via Akt2 switches plakophilin 1 functions from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci. 126, 1832-1844 (2013) PubMed

Lechner, M., Marz, M., Ihling, C., Sinz A., Stadler, PF., Krauss, V., The correlation of genome size and DNA methylation rate in metazoans . Theory Biosci. 132, 47-60 (2012) PubMed

Masada, N., Schaks, S., Jackson, SE., Sinz, A., Cooper, DM., Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8 . Biochemistry 51, 7917-7929 (2012) PubMed

Lipstein, N., Schaks, S., Dimova, K., Kalkhof, S., Ihling, C., Kölbel, K., Ashery, U., Rhee, J., Brose, N., Sinz, A., Jahn, O., Non-conserved Ca2+/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity. Mol Cell Biol. 32, 4628-4641 (2012) PubMed

Kölbel, K., Ihling, C.H., Sinz, A., Analysis of Peptide Secondary Structures by Photoactivatable Amino Acid Analogs Angew. Chem.- Int Edit 51, 12602-12605 (2012) PubMed

Kölbel, K., Ihling, C.H., Kühn, U., Neundorf, I., Otto, S., Stichel, J., Robaa, D., Beck-Sickinger, A.G., Sinz, A.,Wahle, E., Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I. Biochemistry 51, 5463-5475 (2012) PubMed

Sproß, J., Brauch, S., Mandel, F., Wagner, M., Buckenmaier, S., Westermann, B ., Sinz, A., Multidimensional nano-HPLC coupled with tandem mass spectrometry for analyzing biotinylated proteins . Anal Bioanal Chem. 405, 2163-73 (2013).PubMed

Pettelkau, J., Schroeder, T., Ihling, C.H., Olausson, B.E., Kölbel, K., Lange, C., Sinz, A., Structural Insights into Retinal Guanylylcyclase / GCAP-2 Interaction by Cross-Linking and Mass Spectrometry. Biochemistry 51, 4932-4949 (2012) PubMed

Fritzsche, R., Ihling C.H., Götze, M., Sinz, A., Optimizing the enrichment of cross-linked products for mass spectrometric protein analysis . Rapid Commun Mass Spectrom . 26, 653-658 (2012) PubMed

Sproß, J., Sinz, A., Monolithic columns with immobilized monomeric avidin: preparation and application for affinity chromatography . Anal Bioanal Chem. 402, 2395-405 (2012) PubMed

Krause, K., Boisnard, A., Ihling, C., Ludgate, M., Eszlinger, M., Krohn, Sinz, A., Fuhrer, D., Comparative proteomic analysis to dissect differences in signal transduction in activating TSH receptor mutations in the thyroid. Int J Biochem Cell Biol . 179, 3066-3074 (2012) PubMed

Götze, M., Pettelkau, J., Schaks, S., Bosse, K., Ihling, C.H., Krauth, F., Fritzsche, R., Kühn, U., Sinz., A., StavroX - A Software for Analyzing Crosslinked Products in Protein Interaction Studies. J Am Soc Mass Spectrom. 23, 76-87 (2012) PubMed

Soboh, B., Pinske, C ., Kuhns, M., Waclawek, M., Ihling, C., Trchounian, K., Sinz, A., Sawers, R.G., The respiratory molybdo-selenoprotein formate dehydrogenase of Escherichia coli have hydrogen: benzyl viologen oxidoreductase activity . BMC Microbiol . 11, 173-184 (2011) PubMed

Pinske, C ., Krüger, S., Soboh, B., Ihling, C., Kuhns, M., Baussemann, M., Jaroschinsky, M., Sauer, C., Sargent, F., Sinz, A., Sawers, R.G., Efficient electron transfer from hydrogen to benzyl viologen by the [NiFe]-hydrogenases of Escherichia coli is dependent on the coexpression of the iron-sulfur cluster-containing small subunit . Arch Microbiol. 193, 893-903 (2011) PubMed

Kuhfahl, S., Hauburger, A., Thieme, T., Groppe, J., Ihling, C., Tomic, S., Schutkowski, M., Sinz, A., Schwarz,E., Identification of a core domain within the proregion of bone morphogenetic proteins that interact with the dimeric, mature domain . Biochem Biophys Res Commun 408, 300-305 (2011) PubMed

Nimpsch, A., Schibur, S., Ihling, C., Riemer, T., Huster, D., Schiller, J., Quantitative analysis of denatured collagen by collagenase digestion and subsequent MALDO-TOF mass spectrometry. Cell Tissue Res. 343, 605-617 (2011) PubMed

Müller, M.Q., Zeiser J.J., Dreiocker, F., Pich, A., Schäfer, M, Sinz, A., A universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis. Rapid Commun Mass Spectrom. 25, 155 –161 (2011) PubMed

Kalkhof, S., Witte, K., Ihling, C. H., Müller, M. Q., Keller, M. V., Haehn, S., Smyth, N., Paulsson, M., Sinz, A., A Novel Disulfide Pattern in Laminin-Type Epidermal Growth Factor-like (LE) Modules of Laminin β1 and γ1 Chains. Biochemistry 49, 8359–8366 (2010) PubMed

Müller, M.Q., Dreiocker, F., Ihling, C.H., Schäfer, M., Sinz, A., Cleavable Cross-Linker for Protein Structure Analysis: Reliable Identification of Cross-Linking Products by Tandem MS, Anal. Chem. 82, 6958–6968 (2010) PubMed

Kalkhof, S., Haehn, S., Paulsson, M., Smyth, N., Meiler, J., Sinz, A., Computational Modeling of Laminin N-Terminal Domains Using Sparse Distance Constraints from Disulfide Bonds and Chemical Cross-Linking, Proteins: Structure, Function and Bioinformatics 78 3409-3427 (2010) PubMed

Schröder-Tittmann, K., Bosse-Doenecke, E., Reedtz-Runge, S., Ihling, C., Sinz, A., Tittmann, K., Rudolph, R. Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon-like peptide-1 receptor. Biochemistry 49, 7956–7965 (2010) PubMed

Müller, M.Q., Dreiocker, F., Ihling, C.H., Schäfer, M., Sinz, A. Fragmentation Behavior of a Thiourea-Based Reagent for Protein Structure Analysis by Collision-Induced Dissociative Chemical Cross-Linking. J. Mass Spectrom. 45, 880–891 (2010) PubMed

Temme, C., Zhang, L., Kremmer, E., Ihling, C., Chartier, A., Sinz, A., Simonelig, M., Wahle, E. Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.
RNA
16, 1356–243 (2010) PubMed

Hoffmann, A., Müller, M.Q., Gloser, M., Sinz, A., Rudolph, R., Pfeifer, S. Recombinant Production of Bioactive Human TNF-alpha by SUMO-fusion system – High Yields from Shake-flask Culture. Protein Expr. Purif. 72, 238–243 (2010). PubMed

Sproß, J. and Sinz, A. A Capillary Monolithic Trypsin Reactor for Efficient Protein Digestion in Online and Offline Coupling to ESI and MALDI Mass Spectrometry. Anal. Chem. 82, 1434–1443 (2010) PubMed

Krauth, F., Dahse, H.M., Rüttinger, H.H., Frohberg, P. Synthesis and characterization of novel 1,2,4-triazine derivatives with antiproliferative activity. Bioorg. Med. Chem., 18, 1816–1821 (2010). PubMed

Dreiocker, F.*, Müller, M.Q.*, Sinz, A., Schäfer, M., Collision-Induced Dissociative Chemical Cross-Linking Reagent for Protein Structure Characterization: Applied Edman Chemistry in the Gas Phase.  J. Mass Spectrom. 45, 178–189 (2010) PubMed
* both authors contributed equally

Sproß, J. and Sinz, A., Immobilized Monolithic Enzyme Reactors for Application in Proteomics and Pharmaceutics. Anal. Bioanal. Chem. 395, 1583–1588 (2009) PubMed entry

Krauth, F., Ihling, C., Rüttinger, H.H. and Sinz, A., Heterobifunctional Isotope-labeled Amine-Reactive Photo-Cross-Linker for Structural Investigation of Proteins by MALDI-TOF/TOF and ESI-LTQ-Orbitrap Mass Spectrometry. Rapid Commun. Mass Spectrom. 23, 2811–2818 (2009) PubMed entry

Dimova, K., Kalkhof, S., Pottratz, I., Ihling, C., Rodriguez-Castaneda, F., Liepold, T., Griesinger, C., Brose, N., Sinz, A., and Jahn, O. Structural Insights into the Calmodulin-Munc13 Interaction Obtained by Cross-Linking and Mass Spectrometry. Biochemistry 38, 5908–5921 (2009) PubMed entry

Müller, M.Q., de Koning, L.J., Schmidt, A., Ihling, C., Syha, Y., Rau, O., Mechtler, K., Schubert-Zsilavecz, M., and Sinz, A., An Innovative Method to Study Target Protein-Drug Interactions by Mass Spectrometry. J. Med. Chem. 52, 2875–2879 (2009) PubMed entry

Bauer, K., Kretzschmar, A.K., Cvijic, H., Blumert, C., Löffler, D., Brocke-
Heidrich, K., Schiene-Fischer, C., Fischer, G., Sinz, A., Clevenger, C.V. and Horn , F., Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. Oncogene 28, 2784–2795 (2009) PubMed entry

Manolaridis, I.,  Mumtsidu, E.,  Konarev, P., Makhov, A.M., Fullerton, S.F., Sinz, A., Kalkhof, S., McGeehan, J.E.,  Carey, P.D., Griffith, J.D., Svergun, D.  Kneale, G.G. and Tucker, P.A., Structural and Biophysical Characterization of the Components of the Herpes Simplex Virus-1 Replication Origin. J. Biol. Chem. 284, 16343–16353 (2009) PubMed entry

MacDougall, D., Wachten, S., Ciruela, A., Sinz, A. and Cooper, D.M.F., Separate Elements within a Single IQ-like Motif in Adenylyl Cyclase Type 8 Impart Ca2+/CaM Stimulation and Autoinhibition. J. Biol. Chem. 284, 15573–15588 (2009) PubMed entry

Krauth, F., Friedemann, R., Rüttinger, H.H., and Frohberg, P. Open-chain and cyclic amidrazones forming persistent radicals. An electrochemical and quantum chemical study. ARKIVOC VII, 150–164 (2009)

Kölbel, K., Ihling, C., Bellmann-Sickert, K., Neundorf, I., Beck-Sickinger, A. G., Sinz, A., Kühn, U., and Wahle, E. Type I protein arginine methyl transferases PRMT1 and 3 act distributively.
J. Biol. Chem. 284, 8274–8282 (2009) PubMed entry

Müller, M.Q., Roth, C., Sträter, N. and Sinz, A., Expression and Purification of the Ligand-Binding Domain of Peroxisome Proliferator-Activated Receptor alpha. Protein Expr. Purif. 62, 185–189 (2008) PubMed entry

Kalkhof, S. and Sinz, A., Chances and Pitfalls of Chemical Cross-Linking with Amine-Reactive N-Hydroxy Succinimide Esters. Anal. Bioanal. Chem. 392, 305–312 (2008) PubMed entry

Kalkhof, S., Haehn, S., Ihling, C., Smyth, N. and Sinz, A., Determination of Disulfide Bond Patterns in Laminin ß1 Chain N-Terminal Domains by Nano-High Performance Liquid Chromatography/Matrix-Assisted Laser Desorption/Ionization Time-of-Flight/Time-of-Flight Mass Spectrometry. Rapid Commun. Mass Spectrom. 22, 1933–1940 (2008) PubMed entry

Schulz, D.M., Kalkhof, S., Schmidt, A., Ihling, C., Stingl, C., Mechtler, K., Zschörnig, O. and Sinz, A., Annexin A2/p11 Interaction: New insights Into Annexin A2 Tetramer Structure by Chemical Cross-Linking, High-Resolution Mass Spectrometry, and Computational Modeling. Proteins 69, 254–269 (2007) PubMed entry

Pluder, F., Sinz, A. and Beck-Sickinger, A.G., Proliferative Effect of Calcitonin Gene-related Peptide is Induced by at least Five Proteins as Identified by Proteome Profiling. Chem. Biol. Drug Des. 69, 14–22 (2007) PubMed entry

Stingl, C.*, Ihling, C.*, Ammerer, G., Sinz, A. and Mechtler, K., Application of Different Fragmentation Techniques for the Analysis of Phosphopeptides using a Hybrid Linear Ion Trap-FTICR Mass Spectrometer. Biochim. Biophys. Acta- Proteins and Proteomics 1764, 1842–1852 (2006) PubMed entry
* both authors contributed equally

Krause, K., Schierhorn, A., Sinz, A., Wissmann, J.D., Beck-Sickinger, A.G., Paschke, R. and Führer, D., Toward the Application of Proteomics to Human Thyroid Tissue. Thyroid 16, 1131–1143 (2006) PubMed entry

Ihling, C., Schmidt, A., Kalkhof, S., Stingl, C., Mechtler, K., Haack, M., Schulz, D.M., Cooper, D.M.F., Beck-Sickinger, A.G. and Sinz, A., Isotope-Labeled Cross-Linkers and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Structural Analysis of a Protein/Peptide Complex. J. Am. Soc. Mass Spectrom. 17, 1100–1113 (2006) PubMed entry

Schmitt, A., Meiners, I., Schmitt, J., Nöller, J., Ihling, C., Münch, G., Sinz, A. and Nieber, K., Two analytical methods to study the interaction of AGEs with cell surface proteins. J. Biochem. Biophys. Methods 65, 121–136 (2005) PubMed entry

Sinz, A., Kalkhof, S. and Ihling, C., Mapping Protein Interfaces by a Trifunctional Cross-Linker Combined with MALDI-TOF and ESI-FTICR Mass Spectrometry. J. Am. Soc. Mass Spectrom. 16, 1921–1931 (2005) PubMed entry

Schmidt, A., Kalkhof, S., Ihling, C., Cooper, D.M.F. and Sinz, A., Mapping Protein Interfaces by Chemical Cross-Linking and FTICR Mass Spectrometry: Application to a Calmodulin/Adenylyl Cyclase 8 Peptide Complex. Eur. J. Mass Spectrom. 11, 525–534 (2005) PubMed entry

Ihling, C. and Sinz, A., Proteome Analysis of Escherichia coli using High-Performance Liquid Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Proteomics 5, 2029–2042 (2005) PubMed entry

Kalkhof, S., Ihling, C., Mechtler, K. and Sinz, A., Chemical Cross-Linking and High-Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Protein Interaction Analysis: Application to a Calmodulin/Target Peptide Complex. Anal. Chem. 77, 495–503 (2005) PubMed entry

Berger, K., Wissmann, D., Ihling, C., Kalkhof, S., Beck-Sickinger, A., Sinz, A., Paschke, R., Führer, D., Quantitative proteome analysis in benign thyroid nodular disease using the fluorescent ruthenium II tris(bathophenanthroline disulfonate) stain. Mol. Cell. Endocrinol. 227, 21–30 (2004) PubMed entry

Sinz, A. and Wang, K., Mapping Spatial Proximities of Sulfhydryl Groups in Proteins Using a Fluorogenic Cross-Linker and Mass Spectrometry. Anal. Biochem. 331, 27–32 (2004) PubMed entry

Schulz, D.M., Ihling, C., Clore, G.M. and Sinz, A., Mapping the Topology and Determination of a Low Resolution Three-Dimensional Structure of the Calmodulin-Melittin Complex by Chemical Cross-Linking and High-Resolution FTICR Mass Spectrometry: Direct Demonstration of Multiple Binding Modes. Biochemistry 43, 4703–4715 (2004) PubMed entry

Schulz, D.M. and Sinz, A., Chemisches Cross-Linking und Massenspektrometrie zur strukturellen und funktionellen Charakterisierung von Proteinen. BIOSpektrum 10, 45–48 (2004)

Sinz, A., Chemical Cross-Linking and Mass Spectrometry for Mapping Three-Dimensional Structures of Proteins and Protein Complexes. J. Mass Spectrom. 38, 1225–1237 (2003) PubMed entry

Sinz, A., Jin, A.J. and Zschörnig, O., Evaluation of the Metal Binding Properties of a Histidine-Rich Fusogenic Peptide by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J. Mass Spectrom. 38, 1150–1159 (2003) PubMed entry

Dihazi, G.H. and Sinz, A., Mapping Low-Resolution Three-Dimensional Protein Structures Using Chemical Cross-Linking and Fourier Transform Ion-Cyclotron Resonance Mass Spectrometry. Rapid Commun. Mass Spectrom. 17, 2005–2014 (2003) PubMed entry

Ihling, C., Berger, K., Höfliger, M.M., Führer, D., Beck-Sickinger, A.G. and Sinz, A., Nano-High-Performance Liquid Chromatography Combined with Nano-Electrospray Ionization Fourier Transform Ion-Cyclotron Resonance Mass Spectrometry for Proteome Analysis. Rapid Commun. Mass Spectrom. 17, 1240–1246 (2003) PubMed entry

Sinz, A., Bantscheff, M., Mikkat, S., Ringel, B., Drynda, S., Kekow, J., Thiesen, H.J. and Glocker, M.O., Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis., Electrophoresis 23, 3445–3456 (2002) PubMed entry

Sinz, A. and Wang, K., Mapping protein interfaces with a fluorogenic cross-linker and mass spectrometry: Application to nebulin-calmodulin complexes. Biochemistry 40, 7903–7913 (2001) PubMed entry

Kawamura, M., Eisenhofer, G., Kopin, I.J., Kador, P.F., Lee, Y.S., Tsai, J.-Y., Fujisawa, S., Lizak, M.J., Sinz, A. and Sato, S., Aldose reductase: A key enzyme in norepinephrine metabolism in rats. Biochem. Pharmacol. 58, 517–524 (1999) PubMed entry

Sinz, A., Matusch, R., van Elsaecker, F., Santisuk, T., Chaichana, S. and Reutrakul, V., Phenolic Compounds from Anomianthus dulcis. Phytochemistry 50, 1069–1072 (1999)

Sinz, A., Matusch, R., Kaempchen, T., Fiedler, W., Schmidt, J., Santisuk, T., Chaichana, S., Reutrakul, V. and Wangcharoentrakul, S., Novel Acetogenins from the Leaves of Dasymaschalon sootepense. Helv. Chim. Acta 81, 1608–1615 (1998)

Sinz, A., Matusch, R., Santisuk, T., Chaichana, S. and Reutrakul, V., Flavonol Glycosides from Dasymaschalon sootepense. Phytochemistry 47, 1393–1396 (1998) PubMed entry